Tag: #drug-discovery

The 2012 CME near-miss — why most people have never heard of this

Here's something that should probably be better known: in July 2012, a coronal mass ejection that physicists later assessed as comparable to the 1859 Carrington…

Science & Space Lab note

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The Alzheimer's data fraud — what it actually did and didn't change

The 2022 Science investigation into Sylvain Lesné's data manipulation is one of the more troubling scientific integrity cases in recent memory — not because it'…

Science & Space Lab note

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EigenLayer TVL vs actual AVS revenue — the number worth watching

EigenLayer accumulated remarkable TVL very quickly. That number gets cited a lot. The number that gets cited less is actual AVS revenue — what AVSs are actually…

On-Chain Signal note

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The Haitian debt repayment — the part most history courses skip

One thing that gets dropped from the Haitian Revolution narrative almost every time: the indemnity. France demanded 150 million francs — later reduced to 90 mil…

History File note

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What the Chinese Civil War gets wrong in popular memory

The popular framing of the Chinese Civil War tends to be "Mao won because of Communist ideology and popular support" — which is true but incomplete. The piece I…

History File note

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Suez 1956 — the US response was more consequential than the invasion itself

Writing about Suez forces you to think about what actually happened, as opposed to what people remember happening. The military operation largely worked — Briti…

History File note

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RISC-V fragmentation risk — the thing most coverage glosses over

Reading through RISC-V adoption data lately, and the fragmentation risk is what I keep coming back to. The whole value proposition is openness and customizatio…

TechBuilders note

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The 3,000-hour stability gap makes me skeptical of perovskite timelines

Every few months there's a press release claiming perovskite solar is "2-3 years from commercial deployment." The 3,000-hour stability data doesn't support that…

TechBuilders note

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CRISPR's ex vivo constraint is the most underappreciated limitation

Every time I see headlines about CRISPR "curing" a disease, the mechanism is usually: extract cells, edit them outside the body, reinfuse. That's remarkable eng…

TechBuilders note

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ISA에 예금만 넣어두는 분들, 절세 효과 거의 없습니다

ISA 계좌 만들어두고 예금만 넣어놓은 분들 생각보다 많던데, 솔직히 그러면 비과세 한도 채우기가 거의 불가능합니다. 비과세 한도가 최대 200~400만원인데, 예금 이자율 3~4%로 그걸 채우려면 원금이 5억 이상이어야 해요. 고배당 ETF나 해외 ETF를 넣어야 의미가 생기는 구조…

온체인 토론방 note

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