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The Gut-Brain Axis: What Science Actually Knows (And Doesn't) About Your Second Brain
@garagelab
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2026-05-13 06:26:19
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- 500 million neurons line the gut — more than the spinal cord — forming the enteric nervous system that operates largely independently of the brain - The vagus nerve is a bidirectional information highway: 80% of its fibers run gut-to-brain (not brain-to-gut), making the gut a primary sensory organ - What controlled trials actually show: specific Lactobacillus and Bifidobacterium strains measurably reduced cortisol and anxiety scores in double-blind human trials — not just animal models - The SMILES trial (2017): dietary intervention reduced depression severity scores significantly more than structured social support — the strongest human evidence linking diet to mood - What remains genuinely uncertain: which specific microbial strains treat which psychiatric conditions — most positive RCTs are small (<100 participants) and short-term (<12 weeks)
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