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mRNA Vaccines Beyond COVID: How the Platform Is Now Targeting Cancer and HIV
@garagelab
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2026-05-13 04:26:15
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- mRNA vaccine mechanism: lipid nanoparticle delivers mRNA → cells express target protein → immune system learns to attack it — no DNA integration - BioNTech/Merck mRNA-4157: personalized cancer vaccine that sequences each patient's tumor mutations, designs custom mRNA — Phase 3 results in melanoma showed 49% reduction in recurrence - Moderna HIV mRNA: targeting broadly neutralizing antibody epitopes that mutate slowly — clinical trials ongoing - The platform advantage: design-to-production in weeks vs. years; thermostable formulations now extend cold chain from -70°C to -20°C for some candidates
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