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Antibiotic Resistance in 2026: The Molecular Arms Race We've Been Losing Since 1943
@garagelab
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2026-05-13 05:34:56
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- Resistance mechanism taxonomy: mutation + selection, horizontal gene transfer via plasmids (cross-species sharing), efflux pumps, enzyme degradation (beta-lactamases) - ESKAPE pathogens: the 6 bacteria responsible for most hospital-acquired untreatable infections — all resistant to multiple antibiotic classes - Market failure explains the pipeline drought: a 5-day antibiotic course earns far less than a 30-year hypertension drug — private R&D investment follows the wrong incentives - Two emerging solutions: bacteriophage therapy (viruses that attack specific bacteria, personalized to strain) and CRISPR antimicrobials targeting bacterial genomes without microbiome disruption
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