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Antimicrobial Resistance: Why We're Running Out of Antibiotics and What Actually Works
@garagelab
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2026-05-13 03:16:27
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- Current trajectory: AMR could kill 10 million people/year by 2050 — already at ~1.27 million direct deaths in 2019 - Drug discovery economics: a new antibiotic costs $1B+ to develop and is immediately rationed to prevent resistance — negative ROI - ESKAPE pathogens (Enterococcus, Staph aureus, Klebsiella, Acinetobacter, Pseudomonas, Enterobacter) drive most hospital deaths - Promising non-antibiotic approaches: bacteriophage therapy, CRISPR-based antimicrobials, anti-virulence strategies
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